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Recent years, cancer treatment has become a large Medicine a hot research workers, including monoclonal antibody therapy targeting the tumor showed good prospects. Focus of their research focused on the antibody and chemical drugs,[link widoczny dla zalogowanych], enzymes, radionuclides, toxins and biological agents coupled directly after induction of anti-tumor or tumor cells using antibodies to promote apoptosis and inhibit tumor angiogenesis and so on. Currently, the international cancer treatment-related antibodies and mainly focused on the role of the antibody with the coupling material directly kill tumor cells, using antibodies to promote tumor cell apoptosis and inhibit tumor angiogenesis and so on.
Key words monoclonal antibody tumor antibodies
2.2 antibody directed enzyme-coupled antibody and the tumor cell surface by antigen specific binding to the specificity of prodrug activating enzyme coupled with the monoclonal antibody, directed some input to the target cells and then injected precursor drugs, to the role of the enzyme into the active drug, thereby killing tumor cells. Used as a precursor of the current anti-cancer drug laetrile pills have, nitrogen mustard, podophyllotoxin ethylidene glucoside, adriamycin, mitomycin. As the guiding prodrug activation enzyme alkaline phosphatase, penicillin V or G amidase, carboxylic phthalocyanine enzyme, thymidine enzyme, the enzyme β glucosaminidase enzymes and collagenase IV and so on.
2.1 antibody coupled with chemotherapy drugs now, more domestic and foreign research coupled with the monoclonal antibody Pingyangmycin chemical drugs, daunorubicin, mitomycin, doxorubicin (A adriamycin), cisplatin, and Changchun alkali derivatives. Remsen et al [3] in a rabbit model of experimental brain tumors,[link widoczny dla zalogowanych], the use of doxorubicin and the monoclonal antibody BR96 formed by the coupling material, through the blood-brain barrier significantly inhibited the tumor. Liu Xiaoyun, etc. [4] prepared Fab 'fragments and pingyangmycin (pYm) coupled physical Fab'-pYm, coupled material found on liver cancer cell growth and the C26 mice inoculated with spleen liver tumor inhibition was stronger dose of monoclonal antibody drugs in other pYm; while also targeting agents by liposomes targeted therapy as a cancer chemotherapy drug, the use of liposome drug-oriented targets for selectively killing cancer cells and inhibit the reproduction of cancer cells to increasing the role of efficacy and a high degree of orientation. Liposomes has been listed with ethyl compound fluorouracil polyphase liposome, camptothecin polyphase liposome, liposomal doxorubicin and paclitaxel liposome and so on. Wangjia Lei et al [5] paclitaxel liposome and paclitaxel in the treatment of lung cancer and efficacy of breast cancer cases showed that paclitaxel liposome treatment of non-small cell lung cancer and breast cancer more effective and safer. Hosokawa et al [6] will contain a number of coupling doxorubicin liposome monoclonal antibody fragment F (ab) 2 form complexes Mcc465,[link widoczny dla zalogowanych], in the treatment of gastrointestinal cancer clinical trials to obtain a good therapeutic effect.
2 monoclonal antibodies in cancer therapy
Cancer is a serious threat to human health, genetic disease, is the somatic cells of acquired changes in DNA lead to uncontrolled cell proliferation, and this proliferation continued to attack due to the surrounding normal tissue [2].
Monoclonal antibody (monoclonal antibody) has been self-discovery will become specific human cells to identify and combat invasive alien pathogen resistance resulting from a biological material, called monoclonal antibodies. It has high sensitivity and specificity, high efficiency, low toxicity and so on. Monoclonal antibody currently used mainly for diagnosis of various diseases, the drug preparation is also increasingly improved. Preparation of monoclonal antibodies have already made good results. Currently, there are 500 species worldwide diagnostic and therapeutic monoclonal antibodies on the market, more than 100 used in clinical studies [1], according to statistics,[link widoczny dla zalogowanych], by the end of 2004? 02, the U.S. FDA has approved for clinical treatment of 18 monoclonal antibody drugs in vivo; China has also successfully developed more than 300 monoclonal antibodies, and has been used in cancer therapy.

1 cancer treatment status

Monoclonal antibodies in the treatment of cancer in Progress

Abstract review the monoclonal antibody in the treatment of tumors of progress. Monoclonal antibodies in the diagnosis and treatment of cancer has been widely used research and clinical application of the technology made a significant breakthrough. More articles related to topics：

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