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Urokinase-type plasminogen activator system in laryngeal carcinoma and its significance

Between the prognosis is significantly different , because the tumor tissue PAI -1 release from the primary tumor to increase the blood circulation of cancer cells into the site and then implanted in the distance is very important,[link widoczny dla zalogowanych], because in the transfer of new sites Stromal PAI -1 requires the formation of uPA -mediated blockade of extracellular matrix degradation l5J. Therefore , PAI -1 in the plasminogen activator system may play an important regulator of tumor cells or to prevent the degradation of the protective agent itself and not the system alone inhibitor llJ. The results suggest that multiple factors : lymph node metastasis and recurrence ,[link widoczny dla zalogowanych], uPA and PAI -2 is an independent prognostic factor. Prognostic value of clinical staging in this group may be the middle and a higher percentage of patients with advanced related to follow-up data in all clinical stages of no significance l8J. In short , through this set of data on uPA,[link widoczny dla zalogowanych], PAI. 1 and PAl -2 test , indicating that they has nothing to do with other clinical pathological parameters ,[link widoczny dla zalogowanych], only possible with metastasis and recurrence , suggesting that tumor cells secrete uPA, PAI -1 and PAI -2 depends on the ability of the biological characteristics of the tumor cells themselves . uPA and PAI -2 in laryngeal cancer may be a new biological prognostic factors. ( See Figure 1-3 This illustration 1-2)