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 Wysłany: Sob 0:01, 26 Mar 2011 Temat postu: DA1受体激动Ò |
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DA1受体激动剂对大鼠离体肺动脉内皮依赖性舒张反应的影响
500523)De-partmentofCardiology，Zhengzhou460Hospital，Zhengzhou4500514)DepartmentofPhysiology，Shan．,~iMedialUnivers／ty，TaⅦ。n030001Keywordscanine；dopaminereceptors；vascularrelaxation；eorotmryarteriesrcerebralarteryAl~tractAim：Tostudythe(DA)receptorsubtypesandfunctionalsignificanceincaninecoronaryandcerebralarteries·blothodS：Vascularngtechniquewasusedfordelemtiningvasorehtxi1gresponsetofenoldopamandPBDAincaninecoronaryandcerebralarteriesResu~$：①DA_receptorsweredistributedinthecoronaryandcerebralarteries，however，agreetvariationintheirfunctionalpotencyexisted；②D如receptorswere0rpi~esentinthecerebrala~eryCoodtl$ion：ToclfytheheterogeneityinsubtypeandrespottsivenessofDAoninthecoronaryand~rebralarteriesmayhelptoevaluatethephysiolnginalsignifianceofDArece~om研究证实外周循环中广泛存在多巴胺(DA)受体‘，．但关于冠状动脉和脑动脉DA受体的亚型类*国家自然科学基金资助项目39230150别与功能意义尚缺少对l：Ui~究．因此，多巴胺受体在调节冠状动脉和脑活动中的功能意义尚不明确。此外，过去多用多巴胺作为研究外周循环多巴胺受体的工具药，然而多巴胺能够刺激多种受体(包括a、B6DaviesMG，HuynhTJ，HagenCharacterizationofdopamine-mediatedrelaxationinexpenmemalveinbypassgraftsJSurgRes，2OOO，92(1j：1037PalmerR砌，AshtonDS，Moncadas．SupplementalL-argini．eduringcardioplegicarrestandrepeffusionavoidsre#an~pastis。chemicinjuryJThoracC~mifovascSurg，1995，110(2)：3028ReesDD．PatillerRMJ．schllIzRets1．CharacterizationoffuFeeingibitorsofendothelialnitricoxidesynthaseinvitroandinvi-vo．BrJPharmacol，1990，101：7469StmademNB，ouayleJM，DaviesNWeta1．Hyperpolarizingva-sedilatorsactivateATP-sensitlvel：mttas~umchannelsinarterialsmo0thmuscle．Science，1989，245：177(2000-12-06收稿车文编辑赵秋民)
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