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njlpkhgea · Wysłany: Nie 0:40, 13 Mar 2011 Temat postu: Aristolochic acid nephropathy _5195

Aristolochic acid nephropathy

. And MCP-1 and AAI transdifferentiation of HKC cells may have significant synergies, and this synergy can be II1 angiotensin receptor blocker (valsartan) inhibition. Frank and other reports, MyoF cable and I can combine synthetic collagen, the increase in extracellular matrix proteins to promote renal interstitial fibrosis and development. 4.3 AA renal ischemia caused by excessive visceral vascular lesions, lead to renal blood disorder,[link widoczny dla zalogowanych], appeared tubular necrosis. Cos) me and other reports, AA can damage the renal vascular wall, the performance of wall hyperplasia, thickening, stenosis, causing ischemia,[link widoczny dla zalogowanych], particularly chronic interstitial ischemia, leading to tubular atrophy and interstitial fibrosis. 44 renal interstitial fibroblasts or activity increased poison caused by direct stimulation of interstitial fibrosis, leading to stromal vascular and tubular lesions. According to the report, AA can directly stimulate the stromal fibroblasts, leading to interstitial fibrosis and subsequent stenosis of small tubes and blood vessels. Although fibroblast roar no significant increase, but its activity was significantly increased. 4.5AA of DNA adducts (DNAadducts) studies have shown that, in CHN patients or animal experiments measured in kidney samples of DNA adducts of AA, can trigger the process of renal interstitial fibrosis and the occurrence of carcinogenic effects, and other causes of kidney disease found no DNA adducts. (Shenyang Pharmaceutical unit) 046 is a disorder such as cell infiltration DepleteuX CHN 33 cases of renal pathology in accordance with the characteristics of quasi-measure medicine may cause renal tubular epithelial cell injury, leading to the bow of renal fibrosis inflammatory cell infiltration quality. Studies of patients with CHN lemma given prednisone, and achieved a certain effect. May interfere with hormone function and T lymphocyte roar media synthesis. Although most scholars believe that such patients for a wide range, less cell interstitial fibrosis, acute renal failure in renal tissue of patients with the existence of CIN, CD8, CD68 cell infiltration. 4.75 a control serotonin (5-HT) Colson and other reports. To intraperitoneal injection of 5 HT induced a rapid progress of ischemic damage and interstitial fibrosis, and measured in blood of patients with CHN to the substance. It can lead to sustained glomerular vasoconstriction, resulting in ischemic renal injury and macrophages proliferated significantly, when asked in a short period of progress in the renal interstitial fibrosis. CHN may be caused by renal interstitial fibrosis in one of the reasons. 4.8 cytoplasmic toxicity data show that renal damage caused by wood-pass, from clinical observation and kidney pathology of view, whether or not withdrawal, AAN was sexual advances; and its renal tubular epithelial cells seen in uniform basophilic protrusion into the lumen material, electron microscopy shows that it is hierarchical structure, composition is unknown, may be wood-products of cell metabolism poisoning, presumably a Other research found that 49 Nortier, CHN within the proximal tubular brush border enzymes of neutral peptide (neutralendopeptidase) content was significantly lower than healthy people, patients with end-stage renal failure is more obvious reduction. Show rapid reduction of the enzyme without irreversible damage to renal proximal tubule structure and affect the total, the results reflect the severity of renal disease. Some people think that plants can not rule out other unknown toxins and AA synergies. Also suggested that non-AA is also the result of plant toxins in renal interstitial fibrosis CHN one of the factors. Another study, AA and proto-oncogenes - ras gene between p53 activation and cancer-related genes,[link widoczny dla zalogowanych], and confirmed its genetic cancer prevention and treatment of toxic 5AAN 5.1 Although prevention of data, the relationship statutory dose Pharmacopoeia Akebia not cause renal toxicity damage. However, there are in the mouth of the dose occurred in the Pharmacopoeia preparations manshuriensis cause renal damage were reported. Therefore, to prevent the occurrence of the disease should be avoided whenever possible application of Chinese medicines containing AA. If you must use a small dose and short-term application is appropriate, or improve processing methods. Reduce AA content, reduce its toxicity. But it must be noted that the low dose can cause kidney damage minority. 5.2 The treatment regimen is not yet mature, mainly to remove the cause, symptomatic treatment. Whether the immune mechanisms involved in disease is unclear. Early application of treatment with prednisone, to a certain extent,[link widoczny dla zalogowanych], achieved a certain effect. Studies have shown that early use of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin Ⅱ receptor I antagonist, can prevent or reduce the formation of interstitial fibrosis. Cordyceps treatment of clinical application are also AAN,[link widoczny dla zalogowanych], achieved a certain effect. For renal function damage, those who enter end-stage renal failure requires the use of alternative therapies, that dialysis or kidney transplantation. (Received :2002 -01-29 Revised: a 02-20 year)