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Rabeprazole enteric-coated capsules decreased vision caused 1 case

(1) the digestive tract with nausea, diarrhea, bloating, constipation reaction; (2) central nervous system response, may have headaches, dizziness, drowsiness, limb weakness, numbness, decreased grip strength, gait disturbance; (3) allergic reactions : rash, urticaria and pruritus; (4) 2% of the patients, there may ATJT, AST, ALT, a GTP, LDH increased total bilirubin. Foreign serious adverse events reported in the literature are: (1) shock; (2) the blood system, a rare cause pancytopenia, thrombocytopenia, agranulocytosis and hemolytic anemia; (3) visual disturbances. The patients taking the drug after symptoms appeared eyes and blurred vision is unclear, and the instructions suggest, cases have appeared consistent with visual impairment, but no relevant reports of domestic literature. The mechanism of vision loss caused is not clear, to be further explored. Gastroenterology doctors in the application of this drug,[link widoczny dla zalogowanych], you should tell patients pay close attention to adverse reactions after treatment, especially in driving vehicles and vessels, engaged in aerial work, machine operations, and operation of precision instruments, who, in order to avoid more serious damage resulting. Received date :2008-12-18 siblings, two associated with the Huanyi Gan aplastic anemia She wins special (324 Hospital of PLA, Department of Hematology, Chongqing 4OOO20) Key words hepatitis B; aplastic anemia literature CLC R556.5 code B Article ID 1004.0188 (2009) 04 - cover four-01doi: 10.3969 / j. issn. 1004-0188.2009.04.058 cases of yellow × ×, 41-year-old sister, due to repeated fatigue, lower extremity skin petechia 5 years, 1 month were increased hospital. Brother: 31 years old, 5 years due to repeated fatigue, increase in the same half of Japanese homes. Two patients were diagnosed at 5 years of hepatitis B, no formal treatment, HBV markers remains positive. Have denied chloramphenicol, sulfonamides, and taking the history of antipyretic analgesic drugs, chemicals and radioactive substances without a history of exposure. Sister of people because of pre-hospital 1 month increased fatigue and skin petechia, in our clinic to leucogen, sand anhydride alcohol treatment of symptomatic improvement was not obvious. Brother six months ago and the symptoms increased to Chongqing Medical University, myeloproliferative bone marrow examinations showed low oral Admission examination: vital signs were stable, no yellow skin and sclera stained,[link widoczny dla zalogowanych], sister of skin below the knee and lower limbs scattered petechiae, younger brother of the body skin ecchymosis, petechiae, no pale conjunctiva, heart, lung was normal, abdominal soft non-tender, liver and spleen ribs no time,[link widoczny dla zalogowanych], liver percussion pain negative. No lower extremity edema. Both hepatitis B HBsAg, HbeAg, HbeAb positive. Abdominal B-are indications of gallbladder polyps, liver, spleen and kidneys were normal. Both underwent bone marrow biopsy prompted admission myeloproliferative low, again for the puncture site, two Guchuan are indications lower bone marrow cell proliferation, granulocyte red ratio (7.6-11): 1 Department of proliferation is low,[link widoczny dla zalogowanych], the lack of naive phase cells, erythroid hyperplasia was low, only occasionally immature red blood cells, mature red blood cells with normal morphology, not seen megakaryocytes, platelets rare lymphocytes increased the proportion of normal morphology, slightly active non-hematopoietic cells, increased the proportion of blood lymphocytes film classification normal morphology. Bone marrow of aplastic anemia prompted the possibility of early large, with a history of hepatitis B re-consider the barrier to Tiopronin so protective, I 50nag intramuscular injection of testosterone propionate, 1 time / d, oral folic acid, vitamin C, B, Shenqi films and so on, diagnosed with a drug discharged. Discussion of viral hepatitis associated aplastic anemia (HAAA) often occurred in the recovery or cure hepatitis, its occurrence rate of less than 1.0% of acute type usually presents clinically, the prognosis is ominous. This 2 cases were diagnosed in 5 years ago, hepatitis B, no formal treatment, HBV markers remains positive. Specific time for the two patients infected with hepatitis B is unknown, may be longer than 5 years,[link widoczny dla zalogowanych], so the onset of hepatitis and aplastic anemia of unknown. Now that the HAAA and the hepatitis virus on hematopoietic stem cells in the direct inhibitory effect on virus-mediated autoimmune abnormalities or produce anti-stem cell antibodies, virus damage bone marrow microenvironment, liver detoxification dysfunction, etc., in the HAAA disease also played a role Research has shown that genetic factors may be associated with HAAA, but the genes and the relationship between hepatitis B study of aplastic anemia has not been reported. These two patients had four brothers and sisters in the same Huanyi Gan, but others had no clinical symptoms and normal routine blood investigations, whether the disease genes to be studied further. Received date :2008-11-19 Issues of national unity: CN51.1361 / R Publication Date: April 20, 2009 Price: 10.00 Annual Price: 120.00 yuan